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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Effects of Progesterone on Sleep: A Possible Pharmacological Treatment for Sleep-Breathing Disorders?

Author(s): M. L. Andersen, L. R. A. Bittencourt, I. B. Antunes and S. Tufik

Volume 13 , Issue 29 , 2006

Page: [3575 - 3582] Pages: 8

DOI: 10.2174/092986706779026200

Price: $65

Abstract

Progesterone is present in a wide spectrum of biological activity within a variety of tissues. This hormone is also known to affect reproduction, sleep quality, respiration, mood, appetite, learning, memory and sexual activity. Progesterone exerts a sleep induction or hypnotic effect and is a potent respiratory stimulant that has been associated to a decrease in the number of central and obstructive sleep apnea episodes in men. The literature also contains a substantial amount of data on the effect of apnea in women with obesityhypoventilation during menopause. This review attempts to outline the specific role of progesterone in normal sleep and breathing as well as its possible therapeutic effects in the treatment of sleep-disordered breathing.

Keywords: Progesterone, sleep, sleep apnea, breathing, hormonal control


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