Abstract
The concept that the genesis of new cells in the adult mammalian brain is negligible has long influenced our perception and understanding of the origin and development of central nervous system (CNS) tumors. The discovery that neurons and glia are produced throughout life from neural stem cells provides new possibilities for candidate precursor cells of CNS neoplasms. The emerging hypothesis is that alterations in the cellular and genetic mechanisms that control adult neurogenesis might contribute to brain tumorigenesis. As such, opportunities become available to identify new therapeutic strategies.
Keywords: Brain tumor, glioma, stem cells, tumorigenesis, neurogenesis, development, genetics, molecular biology, central nervous system neoplasms, medulloblastoma
Current Stem Cell Research & Therapy
Title: Stem Cells in Brain Tumorigenesis and their Impact on Therapy
Volume: 6 Issue: 4
Author(s): Andres Felipe Cardona, Carmen Balana, Diana Torres, Henry Becerra, Leon Dario Ortiz and Camilo E. Fadul
Affiliation:
Keywords: Brain tumor, glioma, stem cells, tumorigenesis, neurogenesis, development, genetics, molecular biology, central nervous system neoplasms, medulloblastoma
Abstract: The concept that the genesis of new cells in the adult mammalian brain is negligible has long influenced our perception and understanding of the origin and development of central nervous system (CNS) tumors. The discovery that neurons and glia are produced throughout life from neural stem cells provides new possibilities for candidate precursor cells of CNS neoplasms. The emerging hypothesis is that alterations in the cellular and genetic mechanisms that control adult neurogenesis might contribute to brain tumorigenesis. As such, opportunities become available to identify new therapeutic strategies.
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Cite this article as:
Felipe Cardona Andres, Balana Carmen, Torres Diana, Becerra Henry, Dario Ortiz Leon and E. Fadul Camilo, Stem Cells in Brain Tumorigenesis and their Impact on Therapy, Current Stem Cell Research & Therapy 2011; 6 (4) . https://dx.doi.org/10.2174/157488811797904317
DOI https://dx.doi.org/10.2174/157488811797904317 |
Print ISSN 1574-888X |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3946 |
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