Abstract
Neurological diseases and related conditions affect an estimated 1 billion of individuals worldwide [1]. There is still no cure for neurological diseases and disorders, barely a few treatments more or less efficient. This mandates the design and development of novel paradigms and strategies, to discover and develop new treatments and cures for these diseases. Neurogenesis occurs in the adult brain of mammals primarily in two regions, the dentate gyrus (DG) of the hippocampus and the subventricular zone, in various species including in humans. Neural progenitor and stem cells have been isolated, propagated and characterized in vitro from the adult brain of mammals, including humans. The confirmation that neurogenesis occurs in the adult brain and neural stem cells (NSCs) reside in the adult central nervous system (CNS) of mammals, opens new avenues and opportunities for treating neurological diseases and injuries [2].
Keywords: Alzheimer disease, depression, drug, hippocampus, neurogenic, neurogenesis, pharmacology, regeneration, therapy, neural stem cells, neurological diseases, nervous system, mossy fiber, granule cells, learning and memory, epilepsy, neurodegenerative disease, animal model, pathology, physiology, memantine, fluoxetine, apigenin, glutamate agonist, piracetam
Central Nervous System Agents in Medicinal Chemistry
Title: Neurogenic Drugs and Compounds to Treat CNS Diseases and Disorders
Volume: 11 Issue: 1
Author(s): Philippe Taupin
Affiliation:
Keywords: Alzheimer disease, depression, drug, hippocampus, neurogenic, neurogenesis, pharmacology, regeneration, therapy, neural stem cells, neurological diseases, nervous system, mossy fiber, granule cells, learning and memory, epilepsy, neurodegenerative disease, animal model, pathology, physiology, memantine, fluoxetine, apigenin, glutamate agonist, piracetam
Abstract: Neurological diseases and related conditions affect an estimated 1 billion of individuals worldwide [1]. There is still no cure for neurological diseases and disorders, barely a few treatments more or less efficient. This mandates the design and development of novel paradigms and strategies, to discover and develop new treatments and cures for these diseases. Neurogenesis occurs in the adult brain of mammals primarily in two regions, the dentate gyrus (DG) of the hippocampus and the subventricular zone, in various species including in humans. Neural progenitor and stem cells have been isolated, propagated and characterized in vitro from the adult brain of mammals, including humans. The confirmation that neurogenesis occurs in the adult brain and neural stem cells (NSCs) reside in the adult central nervous system (CNS) of mammals, opens new avenues and opportunities for treating neurological diseases and injuries [2].
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Cite this article as:
Taupin Philippe, Neurogenic Drugs and Compounds to Treat CNS Diseases and Disorders, Central Nervous System Agents in Medicinal Chemistry 2011; 11 (1) . https://dx.doi.org/10.2174/187152411794961103
DOI https://dx.doi.org/10.2174/187152411794961103 |
Print ISSN 1871-5249 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6166 |
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