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Medicinal Chemistry


ISSN (Print): 1573-4064
ISSN (Online): 1875-6638

Synthesis and Antiviral Evaluation of Bisnoradamantane Sulfites and Related Compounds

Author(s): Elena Valverde, Eva Torres, Salvador Guardiola, Lieve Naesens and Santiago Vazquez

Volume 7, Issue 2, 2011

Page: [135 - 140] Pages: 6

DOI: 10.2174/157340611794859299

Price: $65


The reaction of a series of 1,2-diols with thionyl chloride led to bisnoradamantane sulfites in very good yields. The reaction has also been applied to related polycyclic scaffolds. The compounds have been tested for antiviral activity but none of them showed to be active. Several attempts to generate and trap SO from these polycyclic sulfites have been unsuccessful.

Keywords: Antiviral activity, bisnoradamantanes, polycyclic compounds, sulfites, sulfur monoxide, vesicular stomatitis virus, 1,2-diols, thionyl chloride, adamantane, ring-contracted analogs, memantine, rimantadine

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