Antiviral Activity of 3-methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol and its Derivatives Against Influenza A(H1N1)2009 Virus

Title: Antiviral Activity of 3-methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol and its Derivatives Against Influenza A(H1N1)2009 Virus

Volume: 8 Issue: 4

Author(s): Oleg V. Ardashov, Vladimir V. Zarubaev, Anna A. Shtro, Dina V. Korchagina, Konstantin P. Volcho, Nariman F. Salakhutdinov and Oleg I. Kiselev

Affiliation:

Keywords: Monoterpenoids, para-menthane, Nicotinate, Influenza, Pandemic, Antiviral, Chemotherapy Drugs, Influenza epidemics, Antiviral Chemotherapy, Melaleuca armillars, Methane Series, Anticonvulsant, Anti parkinsonians activiies, Isonicotinoyl Chloride Hydrochloride,, Chicken Embryos, Erythrocytes

Abstract: A number of new derivatives of monoterpenoid with a para-menthane framework 3-methyl-6-(prop-1-en-2- yl)cyclohex-3-ene-1,2-diol (-)-3 were synthesized. The antiviral activity of (-)-3 and its derivatives against the pandemic influenza virus A/California/07/09 (H1N1)v was studied in vitro. Compound (-)-3 was found to be active against this virus (selectivity index 7.5); for mononicotinate (+)-6 the selectivity index was 17. The absolute configuration of compound 6 was shown to be critical for its antiviral activity.

Cite this article as:

V. Ardashov Oleg, V. Zarubaev Vladimir, A. Shtro Anna, V. Korchagina Dina, P. Volcho Konstantin, F. Salakhutdinov Nariman and I. Kiselev Oleg, Antiviral Activity of 3-methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol and its Derivatives Against Influenza A(H1N1)2009 Virus, Letters in Drug Design & Discovery 2011; 8 (4) . https://dx.doi.org/10.2174/157018011794839411