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Letters in Organic Chemistry


ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Stereoselective Synthesis of (S,E)-2-(trimethylsilyl)ethyl 3-hydroxy-7- (tritylthio)hept-4-enoate

Author(s): Zhiyi Yao, Xin Zeng, Wei Yi and Sheng Jiang

Volume 8 , Issue 1 , 2011

Page: [66 - 69] Pages: 4

DOI: 10.2174/157017811794557868

Price: $65


(S,E)-2-(trimethylsilyl)ethyl 3-hydroxy-7-(tritylthio)hept-4-enoate was synthesized from commercially available L-malic acid by the Julia-Kocienski olefination coupling method. This method provides a concise synthetic strategy for (S,E) -3-hydroxy-7-mercaptohept-4-enoic acid.

Keywords: (S,E)-3-hydroxy-7-mercaptohept-4-enoic acid, Julia-Kocienski olefination coupling, L-malic acid

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