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Infectious Disorders - Drug Targets


ISSN (Print): 1871-5265
ISSN (Online): 2212-3989

Drug Discovery in Enteroviral Infections

Author(s): Tzu-Chun Chen and Shin-Ru Shih

Volume 11, Issue 3, 2011

Page: [337 - 345] Pages: 9

DOI: 10.2174/187152611795768060

Price: $65


Enteroviruses (EVs) are common and significant human pathogens in Asia. EV infections can cause a wide spectrum of acute diseases, including CNS complications. These EV infection-related CNS syndromes include acute flaccid paralysis, aseptic meningitis, encephalitis, and even death. Currently, there is no vaccine available for most EVs except for poliovirus; furthermore, there is a lack of clinical antiviral drugs for treating EV-related infections. These shortages reveal the need to develop potent compounds for treating enteroviral infections. This study summarizes the development of drugs for EV-related infections based on molecular targets blocking various steps in the viral replication cycle.

Keywords: Enterovirus, antiviral agent, therapy, inhibition, viral encephalitis, capsid inhibitor, protease inhibitor, polymerase inhibitor, CNS complications, EV infection-related CNS syndromes, acute flaccid paralysis, aseptic meningitis, encephalitis, poliovirus, viral replication cycle

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