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Letters in Organic Chemistry


ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

A New and Direct Synthesis of Chalcones Via TFAA-H3PO4 Mediated C-C Bond Forming Reaction

Author(s): Kavitha Kankanala, Lingam Venkata Reddy, Vangala Ranga Reddy, Khagga Mukkanti and Sarbani Pal

Volume 8 , Issue 1 , 2011

Page: [53 - 59] Pages: 7

DOI: 10.2174/157017811794557750

Price: $65


A number of α,β-unsaturated carboxylic acids were reacted with electron rich arenes or heteroarene in the presence of trifluoroacetic anhydride (TFAA) and H3PO4 at room temperature to give a variety of chalcone derivatives in good to excellent yields. The methodology was used to prepare novel compounds of potential pharmacological significances.

Keywords: Chalcones, TFAA, α, β-unsaturated carboxylic acids, arenes

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