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Letters in Organic Chemistry


ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

NH4Cl Mediated New Protocol for the Synthesis of 5-Arylidene Barbiturates

Author(s): Khalid Mohammed Khan, Muhammad Ali, Momin Khan, Muhammad Taha and Shahnaz Perveen

Volume 8 , Issue 1 , 2011

Page: [28 - 32] Pages: 5

DOI: 10.2174/157017811794557778

Price: $65


Eco-benign method for synthesizing arylidene barbiturates has been developed by using ammonium chloride (NH4Cl) in stoichiometric amount, as an enolization activator, in water. Execution of methodology is simple, products obtained in high yields and the reactions are completed within 30 min. The new methodology does not involve any solvent/solvent extraction while solid products were yielded in all cases which were filtered and washed.

Keywords: Barbituric acid, ammonium chloride, enolization activator, eco-friendly

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