Abstract
Chronic cough seems more common in women than men. The mean ratio of female to male patients with chronic cough is 2.1 (95% CI, 1.6-2.4). Many large population-based studies have clearly demonstrated that females are more likely to suffer from angiotensin-converting enzyme (ACE)-inhibitors induced cough. When small sized cohort studies on chronic cough are reviewed, the mean ratio of female to male patients is 2.5 (95% CI, 1.7-3.3) in patients with gastro-esophageal reflux (GER) associated cough, 3.6 (95% CI, 1.5-5.8) in patients with atopic cough, 1.6 (95% CI, 0.8- 2.5) in eosinophilic bronchitis without asthma, 2.6 (95% CI, 1.8-3.4) in adult cough variant asthma and 1.9 (95% CI, 0.8- 4.7) in childhood cough variant asthma. Thus, it is likely that females are more likely to suffer from chronic cough, especially ACE-inhibitor-induced cough, GER associated cough, atopic cough and probably eosinophilic bronchitis without asthma, all of which are characterised by increased cough reflex sensitivity. In addition, female healthy volunteers have increased cough reflex sensitivity to inhaled capsaicin.
Keywords: Cough, cough reflex, gender, angiotensin-converting enzyme (ACE)-inhibitors, gastro-esophageal reflux (GER), atopic cough, asthma, post-nasal drip (PND), upper airway cough syndrome, cough variant asthma, cough reflex sensitivity, tartaric acid, capsaicin, pre-menopausal, post-menopausal, tussive agent, bronchial, hyperresponsiveness, airway inflammation, citric acid
Current Respiratory Medicine Reviews
Title: Gender Differences in Chronic Cough
Volume: 7 Issue: 1
Author(s): Masaki Fujimura
Affiliation:
Keywords: Cough, cough reflex, gender, angiotensin-converting enzyme (ACE)-inhibitors, gastro-esophageal reflux (GER), atopic cough, asthma, post-nasal drip (PND), upper airway cough syndrome, cough variant asthma, cough reflex sensitivity, tartaric acid, capsaicin, pre-menopausal, post-menopausal, tussive agent, bronchial, hyperresponsiveness, airway inflammation, citric acid
Abstract: Chronic cough seems more common in women than men. The mean ratio of female to male patients with chronic cough is 2.1 (95% CI, 1.6-2.4). Many large population-based studies have clearly demonstrated that females are more likely to suffer from angiotensin-converting enzyme (ACE)-inhibitors induced cough. When small sized cohort studies on chronic cough are reviewed, the mean ratio of female to male patients is 2.5 (95% CI, 1.7-3.3) in patients with gastro-esophageal reflux (GER) associated cough, 3.6 (95% CI, 1.5-5.8) in patients with atopic cough, 1.6 (95% CI, 0.8- 2.5) in eosinophilic bronchitis without asthma, 2.6 (95% CI, 1.8-3.4) in adult cough variant asthma and 1.9 (95% CI, 0.8- 4.7) in childhood cough variant asthma. Thus, it is likely that females are more likely to suffer from chronic cough, especially ACE-inhibitor-induced cough, GER associated cough, atopic cough and probably eosinophilic bronchitis without asthma, all of which are characterised by increased cough reflex sensitivity. In addition, female healthy volunteers have increased cough reflex sensitivity to inhaled capsaicin.
Export Options
About this article
Cite this article as:
Fujimura Masaki, Gender Differences in Chronic Cough, Current Respiratory Medicine Reviews 2011; 7 (1) . https://dx.doi.org/10.2174/157339811794109309
DOI https://dx.doi.org/10.2174/157339811794109309 |
Print ISSN 1573-398X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6387 |
Call for Papers in Thematic Issues
Exposure to PM2.5 components is associated with respiratory diseases
Through continuous research on the relationship between risk factors and health, it has been found that air pollution, especially atmospheric particulate matter pollution, has become one of the main sources of global disease burden. From 1990 to 2022, the concentration of atmospheric particulate matter pollution has increased by more than ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Edtorial [Hot topic: Glucocorticoids from Chemistry to Clinics (Executive Editor: Fortunato Vesce)]
Current Pharmaceutical Design The Emerging Role of the Histamine H4 Receptor in Anti-inflammatory Therapy
Current Topics in Medicinal Chemistry Omalizumab in Children with Severe Allergic Asthma: The Italian Real- Life Experience
Current Respiratory Medicine Reviews Effect of Boswellia serrata on Rat Trachea Contractility In Vitro
The Natural Products Journal Respiratory Syncytial Virus Bronchiolitis and Asthma – Insights from Recent Studies and Implications for Therapy
Inflammation & Allergy - Drug Targets (Discontinued) Evaluation of Oxidative Status with Exhaled Breath 8-isoprostane Levels in Patients with Hyperthyroidism
Endocrine, Metabolic & Immune Disorders - Drug Targets Drug-Induced Anemia and Other Red Cell Disorders: A Guide in the Age of Polypharmacy
Current Clinical Pharmacology Causes of Secretion Retention: Patient Factors, Ventilation, Devices, Drugs
Current Respiratory Medicine Reviews Angiogenesis New Targets for the Development of Anticancer Chemotherapies
Current Pharmaceutical Design The FKBP51-Glucocorticoid Receptor Balance in Stress-Related Mental Disorders
Current Molecular Pharmacology Relevance of Pharmacokinetics and Bioavailability of Intranasal Corticosteroids in Allergic Rhinitis
Recent Patents on Inflammation & Allergy Drug Discovery The Effects of Hydroalcoholic Extract of Pinus eldarica on Hippocampal Tissue Oxidative Damage in Pentylenetetrazole-Induced Seizures in Rat
Current Nutrition & Food Science ADAM8 in Allergy
Inflammation & Allergy - Drug Targets (Discontinued) Interaction of TGF-β with Immune Cells in Airway Disease
Current Molecular Medicine Oral Immune Regulation: A New Mode of Therapy Against Chronic Viral Infections
Recent Patents on Anti-Infective Drug Discovery Self-Assembled Peptide Nanoarchitectures: Applications and Future Aspects
Current Topics in Medicinal Chemistry Molecular Recognition of Tachykinin Receptor Selective Agonists: Insights from Structural Studies
Mini-Reviews in Medicinal Chemistry Preface (Hot Topic: Pulmonary Inflammation Guest Editor: Momtchilo Russo)
Current Drug Targets - Inflammation & Allergy Systemic Therapies for Pancreatic Cancer - The Role of Pharmacogenetics
Current Drug Targets The Role of Antihistamine Drugs in Allergic Disorders
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents