Recent Advances and Future Perspectives of Triazole Analogs as Promising Antiviral Agents

Rajeev      Kharb; Mohammad      Shahar Yar; Probodh      Chander Sharma

Abstract

Emergence of severe viral infections in recent years and limited availability of antiviral chemotherapeutic agents for prevention and treatment of these infections are among the most common causes of human illness and death. Therefore, there is an urgent need to develop antiviral drugs that have a potentially critical role in the prevention and treatment of various fatal and debilitating viral infections. Triazole derivatives occupy a pivotal position in modern medicinal chemistry and several have found applications as medicines. A large volume of research has been carried out on triazole and their derivatives for antiviral activity and pharmacological importance of this scaffold has been well established. This review is primarily addressed to description of the recent advances in the synthesis and evaluation of triazole derivatives as antiviral agents which may facilitate the development of more potent and effective antiviral agents.

Keywords: Antiviral activity, HAART, ribavirin, 1,2,3-triazole, 1,2,4-triazole, tobacco mosaic virus, AIDS, HIV, H1N1, Triazole, respiratory syncytial virus (RSV), infection, hepatitis C infection, Lassa fever, Crimean-Congo hemorrhagic fever, efavirenz, nevirapine, MDBK, BVDV, BHK, Reo, pseudo-type HIV assay, BSC-40 cells, Western Blots, amantadine, ISRE, HFRS, ETAR, zanamivir, ACVR, trovirdine, didadosine