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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Anti-cancer Effect of Spinach Glycoglycerolipids as Angiogenesis Inhibitors Based on the Selective Inhibition of DNA Polymerase Activity

Author(s): N. Maeda, K. Matsubara, H. Yoshida and Y. Mizushina

Volume 11, Issue 1, 2011

Page: [32 - 38] Pages: 7

DOI: 10.2174/138955711793564042

Price: $65

Abstract

Plants contain major glycoglycerolipids, such as monogalactosyl diacylglycerol (MGDG), digalactosyl diacylglycerol (DGDG) and sulfoquinovosyl diacylglycerol (SQDG), in the chloroplast membrane. The bioactivities of purified MGDG, DGDG and SQDG from spinach have been investigated extensively. MGDG and SQDG have been shown to inhibit the activities of mammalian DNA polymerases, but DGDG has no such inhibitory effect. The effect of these glycoglycerolipids on cancer cells, angiogenesis and solid tumor growth might be mediated via their inhibition of replicative DNA polymerase activities. On the basis of these findings, we discuss the mode of action of plant chloroplast glycoglycerolipids as anti-cancer therapeutic agents.

Keywords: Monogalactosyl diacylglycerol (MGDG), digalactosyl diacylglycerol (DGDG), sulfoquinovosyl diacylglycerol (SQDG), DNA polymerase (E.C.2.7.7.7), enzyme inhibitor, cytotoxicity, anti-angiogenesis, anti-tumor effect, DGDG, MGDG, SQDG, silica gel column chromatography, terminal deoxynucleotidyl transferase, Lineweaver-Burk plots, T4 pol, Taq pol, E. coli pol I, human dermal fibroblasts, Western blotting, HL60, HUVECs, cyclodextrin


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