Abstract
Tissue homeostasis is maintained by tight control of signaling events that regulate cell death and cell survival. Apoptosis or programmed cell death plays a key role in maintaining tissue homeostasis under various conditions during normal development and in the adult organism. Thus, defective apoptosis programs contribute to the pathogenesis of various human diseases, for example to cancer formation. In addition, the antitumor activity of most cancer therapies, including chemotherapy, radiotherapy or immunotherapy, is mediated by the activation of apoptosis in cancer cells. Natural compounds including resveratrol have attracted much attention over the last decade both as cancer chemopreventive agents and as cancer therapeutics. To this end, resveratrol inhibits signal transduction pathways that block apoptosis and/or promote cell survival. Insights into the molecular mechanisms of how resveratrol regulates cell survival and cell death signaling is expected to open new avenues for the exploitation of resveratrol in the prevention and treatment of cancer.
Keywords: Apoptosis, resveratrol, cancer
Mini-Reviews in Organic Chemistry
Title: Regulation of Apoptosis and Cell Survival by Resveratrol
Volume: 7 Issue: 4
Author(s): Simone Fulda
Affiliation:
Keywords: Apoptosis, resveratrol, cancer
Abstract: Tissue homeostasis is maintained by tight control of signaling events that regulate cell death and cell survival. Apoptosis or programmed cell death plays a key role in maintaining tissue homeostasis under various conditions during normal development and in the adult organism. Thus, defective apoptosis programs contribute to the pathogenesis of various human diseases, for example to cancer formation. In addition, the antitumor activity of most cancer therapies, including chemotherapy, radiotherapy or immunotherapy, is mediated by the activation of apoptosis in cancer cells. Natural compounds including resveratrol have attracted much attention over the last decade both as cancer chemopreventive agents and as cancer therapeutics. To this end, resveratrol inhibits signal transduction pathways that block apoptosis and/or promote cell survival. Insights into the molecular mechanisms of how resveratrol regulates cell survival and cell death signaling is expected to open new avenues for the exploitation of resveratrol in the prevention and treatment of cancer.
Export Options
About this article
Cite this article as:
Fulda Simone, Regulation of Apoptosis and Cell Survival by Resveratrol, Mini-Reviews in Organic Chemistry 2010; 7 (4) . https://dx.doi.org/10.2174/157019310792246355
DOI https://dx.doi.org/10.2174/157019310792246355 |
Print ISSN 1570-193X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6298 |
Call for Papers in Thematic Issues
Applications of Molecular Descriptors in Physicochemical Properties Research of Organic Compounds
Chemical graph theory is concerned with all aspects of the application of graph theory to various areas of chemistry, including organic, theoretical, mathematical, and computational chemistry, as well as in bioinformatics and computational biology. By the use of the term chemical it is emphasized that one is allowed in chemical ...read more
Navigating the 2D Universe in Organic Chemistry
This special issue explores the transformative impact of two-dimensional (2D) materials on the realm of organic chemistry, unraveling new possibilities for synthesis, functionalization, and applications of organic compounds. Focused on the unique chemistry within this novel dimension, the issue highlights breakthroughs in the field of 2D organic chemistry. Contributions are ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Plant Polyphenols and Tumors: From Mechanisms to Therapies, Prevention, and Protection Against Toxicity of Anti-Cancer Treatments
Current Medicinal Chemistry Airway Fibroblast Secretory Products Enhance Cell Migration
Current Proteomics Polo-Like Kinases (Plks) are Prognostic Markers for Gynecologic Malignancies
Current Women`s Health Reviews A Systems Biology Road Map for the Discovery of Drugs Targeting Cancer Cell Metabolism
Current Pharmaceutical Design Notch Signalling Pathways and Their Importance in the Treatment of Cancers
Current Drug Targets The PI3 Kinase Signaling Pathway in Prostate Cancer
Current Cancer Drug Targets Different 6-Aryl-Fulvenes Exert Anti-proliferative effects on Cancer Cells
Anti-Cancer Agents in Medicinal Chemistry Exogenous Hormonal Regulation in Breast Cancer Cells by Phytoestrogens and Endocrine Disruptors
Current Medicinal Chemistry Effect of Curcumin on Pro-angiogenic Factors in the Xenograft Model of Breast Cancer
Anti-Cancer Agents in Medicinal Chemistry Endometriosis Management: Workflow on Genomics and Proteomics and Future Biomolecular Pharmacotherapy
Current Medicinal Chemistry The mTOR Pathway: A New Target in Cancer Therapy
Current Cancer Drug Targets Epigenetic Remodeling of Chromatin Architecture: Exploring Tumor Differentiation Therapies in Mesenchymal Stem Cells and Sarcomas
Current Stem Cell Research & Therapy Pharmacologic Activation of p53 by Small-Molecule MDM2 Antagonists
Current Pharmaceutical Design Advanced Assessment of the Endogenous Hormone Level as a Potential Biomarker of the Urogenital Tract Cancer
Combinatorial Chemistry & High Throughput Screening Mitochondrial Drug Targets in Cell Death and Cancer
Current Pharmaceutical Design The Molecular Mechanisms of TRAIL Resistance in Cancer Cells: Help in Designing New Drugs
Current Pharmaceutical Design Metformin and Anti-Cancer Therapeutics: Hopes for a More Enhanced Armamentarium Against Human Neoplasias?
Current Medicinal Chemistry Recent Advances in the Synthesis and Anticancer Activity of Some Molecules Other Than Nitrogen Containing Heterocyclic Moeities
Mini-Reviews in Medicinal Chemistry Pore-forming Peptides: A New Treatment Option for Cancer
Current Medicinal Chemistry Properties of the Mesenchymal Endometriotic Stem Cell in the Context of the Immune System and Analysis of its Role in Endometriosis
Recent Patents on Regenerative Medicine