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Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Lithocholic Acid Derivative as a Model for Artificial Receptors: A Raman Study

Author(s): F.M.F. Roleira, E.J. Tavares da Silva, Rui A. Carvalho and M.P.M. Marques

Volume 7 , Issue 8 , 2010

Page: [610 - 617] Pages: 8

DOI: 10.2174/157018010792062731

Price: $65

Abstract

Two lithocholic acid (LCA) derivatives — mono- and diesters (newly synthetised) — are studied for their main conformational preferences, by Raman spectroscopy coupled to theoretical (DFT) methods. Raman bands characteristic of each compound were assigned, allowing an accurate and rapid identification of this kind of systems. The conformational preferences of the LCA diester were related with its ability to function as a model for artificial receptors, displaying a tailored structural profile.

Keywords: Lithocholic acid derivatives, Artificial receptors, Conformational analysis, Raman spectroscopy


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