Synthesis and Antitumor Evaluation of (E)-2-Benzothiazole Hydrazones

Antonio      Francisco Nogueira; Elisa      Carvalho Azevedo; Vitor      Francisco Ferreira; Ana      Jersia Araujo; Evelyne      Alves dos Santos; Claudia      Pessoa; Leticia      Veras Costa-Lotufo; Raquel      Carvalho Montenegro; Manoel      Odorico de Moraes; Thatyana      Rocha Alves Vasconcelos

Abstract

A series of eleven (E)-2-benzothiazole hydrazones were synthesized and evaluated for their in vitro anticancer activities against three neoplastic cancer cells: HL-60 (leukemia), MDAMB-435 (breast) and HCT-8 (colon). Two of them, 3e and 3f, showed good cytotoxicity activity for HL-60. The results also demonstrated that compound 3f seems to be selective to HL-60 cell line, appearing as a good prototype for an antileukemia lead molecule.

Keywords: Benzothiazoles, Hydrazones, Cancer, Cytotoxicity

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Letters in Drug Design & Discovery

Title: Synthesis and Antitumor Evaluation of (E)-2-Benzothiazole Hydrazones

Volume: 7 Issue: 8

Author(s): Antonio Francisco Nogueira, Elisa Carvalho Azevedo, Vitor Francisco Ferreira, Ana Jersia Araujo, Evelyne Alves dos Santos, Claudia Pessoa, Leticia Veras Costa-Lotufo, Raquel Carvalho Montenegro, Manoel Odorico de Moraes and Thatyana Rocha Alves Vasconcelos

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Keywords: Benzothiazoles, Hydrazones, Cancer, Cytotoxicity

Abstract: A series of eleven (E)-2-benzothiazole hydrazones were synthesized and evaluated for their in vitro anticancer activities against three neoplastic cancer cells: HL-60 (leukemia), MDAMB-435 (breast) and HCT-8 (colon). Two of them, 3e and 3f, showed good cytotoxicity activity for HL-60. The results also demonstrated that compound 3f seems to be selective to HL-60 cell line, appearing as a good prototype for an antileukemia lead molecule.

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Francisco Nogueira Antonio, Carvalho Azevedo Elisa, Francisco Ferreira Vitor, Jersia Araujo Ana, Alves dos Santos Evelyne, Pessoa Claudia, Veras Costa-Lotufo Leticia, Carvalho Montenegro Raquel, Odorico de Moraes Manoel and Rocha Alves Vasconcelos Thatyana, Synthesis and Antitumor Evaluation of (E)-2-Benzothiazole Hydrazones, Letters in Drug Design & Discovery 2010; 7 (8) . https://dx.doi.org/10.2174/157018010792062740