Novel dihydropyrazole Derivatives Linked with 4H-Chromene: Microwave-Promoted Synthesis and Antibacterial Activity

Title: Novel dihydropyrazole Derivatives Linked with 4H-Chromene: Microwave-Promoted Synthesis and Antibacterial Activity

Volume: 7 Issue: 6

Author(s): Xin-Hua Liu, Jin-Xin Liu, Lin-Shan Bai, Guo-Lin Lan and Chu-Xiou Pan

Affiliation:

Keywords: Microwave-promoted, synthesis, characterize, dihydropyrazole, 4H-chromene, antibacterial activity

Abstract: Seven novel 6-(1-acetyl-3-methyl-4,5-dihydro-1H-pyrazol-5-yl)-2-amino-4-substituted-phenyl-4H-chromene- 3-carbonitrile derivatives were synthesized and characterized by ESI-MS, 1H NMR and 13C NMR. All of the compounds have been screened for their antibacterial activity. The results show that compounds 7e and 7f displayed significant activity with MIC of 1.562 μg/mL against B. subtilis ATCC 6633.

Cite this article as:

Liu Xin-Hua, Liu Jin-Xin, Bai Lin-Shan, Lan Guo-Lin and Pan Chu-Xiou, Novel dihydropyrazole Derivatives Linked with 4H-Chromene: Microwave-Promoted Synthesis and Antibacterial Activity, Letters in Organic Chemistry 2010; 7(6) . https://dx.doi.org/10.2174/157017810791824847