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Letters in Organic Chemistry


ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Novel dihydropyrazole Derivatives Linked with 4H-Chromene: Microwave-Promoted Synthesis and Antibacterial Activity

Author(s): Xin-Hua Liu, Jin-Xin Liu, Lin-Shan Bai, Guo-Lin Lan and Chu-Xiou Pan

Volume 7, Issue 6, 2010

Page: [487 - 490] Pages: 4

DOI: 10.2174/157017810791824847

Price: $65


Seven novel 6-(1-acetyl-3-methyl-4,5-dihydro-1H-pyrazol-5-yl)-2-amino-4-substituted-phenyl-4H-chromene- 3-carbonitrile derivatives were synthesized and characterized by ESI-MS, 1H NMR and 13C NMR. All of the compounds have been screened for their antibacterial activity. The results show that compounds 7e and 7f displayed significant activity with MIC of 1.562 μg/mL against B. subtilis ATCC 6633.

Keywords: Microwave-promoted, synthesis, characterize, dihydropyrazole, 4H-chromene, antibacterial activity

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