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Current Organic Synthesis


ISSN (Print): 1570-1794
ISSN (Online): 1875-6271

The Asymmetric [C+NC+CC] Coupling Reaction: Development and Application to Natural Product Synthesis

Author(s): P. Garner and H.U. Kaniskan

Volume 7, Issue 4, 2010

Page: [348 - 362] Pages: 15

DOI: 10.2174/157017910791414517

Price: $65


Development of the asymmetric [C+NC+CC] coupling reaction is described. This reaction assembles aldehyde (C), amine (NC), and alkene (CC) components in a predictable and controlled fashion to give highly functionalized pyrrolidines. The utility of the asymmetric [C+NC+CC] coupling reaction is demonstrated by its application to an efficient formal total synthesis of cyanocycline A.

Keywords: Asymmetric synthesis, azomethine ylide cycloaddition, cyanocycline A, multicomponent reaction, pyrrolidine synthesis

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