The Asymmetric [C+NC+CC] Coupling Reaction: Development and Application to Natural Product Synthesis

Title: The Asymmetric [C+NC+CC] Coupling Reaction: Development and Application to Natural Product Synthesis

Volume: 7 Issue: 4

Author(s): P. Garner and H.U. Kaniskan

Affiliation:

Keywords: Asymmetric synthesis, azomethine ylide cycloaddition, cyanocycline A, multicomponent reaction, pyrrolidine synthesis

Abstract: Development of the asymmetric [C+NC+CC] coupling reaction is described. This reaction assembles aldehyde (C), amine (NC), and alkene (CC) components in a predictable and controlled fashion to give highly functionalized pyrrolidines. The utility of the asymmetric [C+NC+CC] coupling reaction is demonstrated by its application to an efficient formal total synthesis of cyanocycline A.

Cite this article as:

Garner P. and Kaniskan H.U., The Asymmetric [C+NC+CC] Coupling Reaction: Development and Application to Natural Product Synthesis, Current Organic Synthesis 2010; 7(4) . https://dx.doi.org/10.2174/157017910791414517