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Protein & Peptide Letters


ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Acafusin, a Dimeric Antifungal Protein from Acacia confusa Seeds

Author(s): Sze Kwan Lam and Tzi Bun Ng

Volume 17, Issue 7, 2010

Page: [817 - 822] Pages: 6

DOI: 10.2174/092986610791306643

Price: $65


A dimeric 34-kDa antifungal protein, designated as acafusin, was purified from Acacia confusa seeds using Q-Sepharose, DEAE-cellulose, Mono S and Superdex S75. It demonstrated antifungal activity toward Rhizoctonia solani with an IC50 of 28 μM. Acafusin inhibited the activity of HIV-1 reverse transcriptase mildly with an IC50 of 80 μM.

Keywords: Acacia confusa, antifungal protein, HIV-1 reverse transcriptase inhibitory

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