Acafusin, a Dimeric Antifungal Protein from Acacia confusa Seeds

Sze      Kwan Lam; Tzi      Bun Ng

Abstract

A dimeric 34-kDa antifungal protein, designated as acafusin, was purified from Acacia confusa seeds using Q-Sepharose, DEAE-cellulose, Mono S and Superdex S75. It demonstrated antifungal activity toward Rhizoctonia solani with an IC50 of 28 μM. Acafusin inhibited the activity of HIV-1 reverse transcriptase mildly with an IC50 of 80 μM.

Keywords: Acacia confusa, antifungal protein, HIV-1 reverse transcriptase inhibitory

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