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Current Alzheimer Research


ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

Imaging as a Strategy for Premortem Diagnosis and Staging of Tauopathies

Author(s): S. Kim, J.R. Jensen, K. Cisek, K.E. Funk, S. Naphade, K. Schafer and J. Kuret

Volume 7, Issue 3, 2010

Page: [230 - 234] Pages: 5

DOI: 10.2174/156720510791050894

Price: $65


Alzheimers disease is diagnosed by postmortem detection of pathological lesions that accumulate in specific brain regions. Although the presence of both β-amyloid plaques and tau-bearing neurofibrillary lesions defines Alzheimers disease, the distribution of neurofibrillary lesions alone correlates strongly with neurodegeneration and cognitive decline. A whole-brain imaging test capable of detecting these lesions in premortem cases could have great potential for staging and differentially diagnosing Alzheimers disease. Here we discuss the challenges in developing a whole-brain imaging approach for detection of this intracellular target.

Keywords: Alzheimer's disease, frontotemporal lobar degeneration, tau, neurofibrillary tangle, paired helical filaments

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