Abstract
Our recent study on Artocarpus odoratissimus (Moraceae) has resulted in the purification of a new prenylated pyranoflavone derivative artosimmin (1) and traxateryl acetate (2). Details of structural elucidations associated with 1 and 2 are reported by combining 1D, 2D NMR and mass spectrometric methods. Compound 2 is obtained for the first time from this species. Furthermore, the biological assay results exhibited compound 1 to be significantly cytotoxic against cancer cell lines (HL-60 & MCF-7) and also possessed antioxidant properties toward 1,1-diphenyl-2-picrylhydrazyl radical (DPPH).
Keywords: Artocarpus odoratissimus, moraceae, pyranoflavone, triterpenoid, cytotoxicity, antioxidant
Letters in Organic Chemistry
Title: Artosimmin- A Potential Anti-Cancer Lead Compound from Artocarpus odoratissimus
Volume: 7 Issue: 3
Author(s): Gwendoline C.L. Ee, Siow H. Teo, Mawardi Rahmani, Chan K. Lim, Yang M. Lim and Choon F.J. Bong
Affiliation:
Keywords: Artocarpus odoratissimus, moraceae, pyranoflavone, triterpenoid, cytotoxicity, antioxidant
Abstract: Our recent study on Artocarpus odoratissimus (Moraceae) has resulted in the purification of a new prenylated pyranoflavone derivative artosimmin (1) and traxateryl acetate (2). Details of structural elucidations associated with 1 and 2 are reported by combining 1D, 2D NMR and mass spectrometric methods. Compound 2 is obtained for the first time from this species. Furthermore, the biological assay results exhibited compound 1 to be significantly cytotoxic against cancer cell lines (HL-60 & MCF-7) and also possessed antioxidant properties toward 1,1-diphenyl-2-picrylhydrazyl radical (DPPH).
Export Options
About this article
Cite this article as:
C.L. Ee Gwendoline, H. Teo Siow, Rahmani Mawardi, K. Lim Chan, M. Lim Yang and F.J. Bong Choon, Artosimmin- A Potential Anti-Cancer Lead Compound from Artocarpus odoratissimus, Letters in Organic Chemistry 2010; 7 (3) . https://dx.doi.org/10.2174/157017810791112379
DOI https://dx.doi.org/10.2174/157017810791112379 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Porphyrins as Radiosensitizing Agents for Solid Neoplasms
Current Pharmaceutical Design Antimalarial Drugs in Pregnancy: A Review
Current Drug Safety Twenty Years of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: Time to Reevaluate their Toxicity
Current Medicinal Chemistry Combinatorial Approaches for the Identification of Brain Drug Delivery Targets
Current Pharmaceutical Design Relevance of Drug Metabolizing Enzyme Activity Modulation by Tea Polyphenols in the Inhibition of Esophageal Tumorigenesis
Medicinal Chemistry Class II Phosphoinositide 3-Kinases as Potential Novel Drug Targets
Current Signal Transduction Therapy Biocompatible Delivery System for Metformin: Characterization, Radiolabeling and In Vitro Studies
Anti-Cancer Agents in Medicinal Chemistry The Hypothalamus and Obesity
Current Drug Targets The Endothelin Axis: A Novel Target for Pharmacotherapy of Female Malignancies
Current Vascular Pharmacology Heregulin in Breast Cancer: Old Story, New Paradigm
Current Pharmaceutical Design Evaluation of Local Injection of Bevacizumab against Triple-Negative Breast Cancer Xenograft Tumors
Current Pharmaceutical Design Histone Variants and Composition in the Developing Brain: Should MeCP2 Care?
Current Topics in Medicinal Chemistry Assays for Identification of Hsp90 Inhibitors and Biochemical Methods for Discriminating their Mechanism of Action
Current Topics in Medicinal Chemistry Future Prospect of RNA Interference for Cancer Therapies
Current Drug Targets GPR40 Carboxylic Acid Receptor Family and Diabetes: A New Drug Target
Current Drug Targets Current Status and Future Directions of Nanoparticulate Strategy for Cancer Immunotherapy
Current Drug Metabolism Histamine as a Potential Adjuvant to Immuno and Radiotherapy for Cancer Treatment: Discovering New Functions for the Oldest Biogenic Amine
Current Immunology Reviews (Discontinued) Isolation of Chlorogenic Acid from Soil Borne Fungi Screlotium rolfsii, their Reversal of Multidrug Resistance and Anti-proliferative in Mouse Lymphoma Cells
Medicinal Chemistry Establishment of Novel Cells Stably Secreting Various Human IL-18 Recombinant Proteins
Current Pharmaceutical Biotechnology Benzofuran: A Key Heterocycle - Ring Closure And Beyond
Mini-Reviews in Organic Chemistry