Abstract
A 26-kDa trypsin inhibitor with an N-terminal sequence resembling storage proteins was purified from moth beans (Phaseolus acutifolius). It dose-dependently inhibited trypsin with an IC50 value of about 0.38 μM. It inhibited [methyl-3H] thymidine incorporation by lymphoma MBL2 cells with an IC50 value of 20 μM.
Keywords: antiproliferative, lymphoma cells, moth bean, purification, storage protein, trypsin inhibitor
Protein & Peptide Letters
Title: A Storage Protein-Like Trypsin Inhibitor from the Moth Bean (Phaseolus acutifolius) with Antiproliferative Activity Toward Lymphoma Cells
Volume: 17 Issue: 6
Author(s): D.Z. Ma, J. Sun, G.Q. Zhang, H.X. Wang and T.B. Ng
Affiliation:
Keywords: antiproliferative, lymphoma cells, moth bean, purification, storage protein, trypsin inhibitor
Abstract: A 26-kDa trypsin inhibitor with an N-terminal sequence resembling storage proteins was purified from moth beans (Phaseolus acutifolius). It dose-dependently inhibited trypsin with an IC50 value of about 0.38 μM. It inhibited [methyl-3H] thymidine incorporation by lymphoma MBL2 cells with an IC50 value of 20 μM.
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Cite this article as:
Ma D.Z., Sun J., Zhang G.Q., Wang H.X. and Ng T.B., A Storage Protein-Like Trypsin Inhibitor from the Moth Bean (Phaseolus acutifolius) with Antiproliferative Activity Toward Lymphoma Cells, Protein & Peptide Letters 2010; 17 (6) . https://dx.doi.org/10.2174/092986610791190408
DOI https://dx.doi.org/10.2174/092986610791190408 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
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