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Letters in Organic Chemistry


ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Novel Derivatives of 1,3-Dimethyl-5-methylenebarbituric Acid

Author(s): Kamal Sweidan, Qutaiba Abu-Salem, Ahmed Al-Sheikh and Ghassan Abu Sheikha

Volume 6, Issue 8, 2009

Page: [669 - 672] Pages: 4

DOI: 10.2174/157017809790442934

Price: $65


The ability of the pyridinium adduct of 1,3-dimethyl-5-methylenebarbituric acid (2) to undergo nucleophilic substitution reaction has been examined. Various types of nucleophiles, including cyanide, barbiturate, sulfide anions and 1,2-bis(diphenylphosphino)ethane substitute the pyridinium fragment in 2 leading to synthesis of new organic derivatives.

Keywords: 1,3-dimethyl-2,4,6(1H,3H,5H)-pyrimidinetrione (1,3-dimethylbarbituric acid), zwitterionic pyridinium adduct, nucleophilic substitution reaction

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