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Current Topics in Medicinal Chemistry


ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Small-Molecule Modulators of the NF-κB Pathway Newly Identified by a Translocation-Based Cellular Assay

Author(s): Yuli Xie, Alison Rinderspacher, Yidong Liu, Gangli Gong, Deborah H. Smith, Michael Wyler, Lars Branden and Shi-Xian Deng

Volume 9, Issue 13, 2009

Page: [1172 - 1180] Pages: 9

DOI: 10.2174/156802609789753617

Price: $65


Nuclear factor kappa B (NF-κB) is an important transcription factor. Aberrant regulation of the NF-κB pathway is frequently observed in a number of major ailments such as cancer and inflammatory diseases. Hence NF-κB modulators have been intensely pursued for their potential therapeutic applications. Numerous reviews have described recent progress in the development of these agents. More recently, a variety of structurally and functionally novel small molecules, identified through high-throughput screens conducted within the Molecular Libraries Screening Center Network (MLSCN) of the NIH Roadmap for Medical Research, have been added to the current list of NF-κB regulators. This review will discuss the inhibitors and activators newly discovered by Columbias Molecular Libraries Screening Center (MLSC) using a well-designed and stable cellular assay.

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