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Current Topics in Medicinal Chemistry


ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Cognitive Impairment and Dementia in Patients with Parkinson Disease

Author(s): James B. Leverenz, Joseph F. Quinn, Cyrus Zabetian, Jing Zhang, Kathleen S. Montine and Thomas J. Montine

Volume 9, Issue 10, 2009

Page: [903 - 912] Pages: 10

DOI: 10.2174/156802609789378218

Price: $65


Parkinson disease (PD) is an already prevalent neurodegenerative disease that is poised to at least double over the next 25 years. Although best known for its characteristic movement disorder, PD is now appreciated commonly to cause cognitive impairment, including dementia, and behavioral changes. Dementia in patients with PD is consequential and has been associated with reduced quality of life, shortened survival, and increased caregiver distress. Here we review clinical presentation and progression, pathological bases, identification of genetic risk factors, development of small molecule biomarkers, and emerging treatments for cognitive impairment in patients with PD.

Keywords: Parkinson disease, cognitive impairment, dementia, Alzheimer disease, Demenita with Lewy bodies

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