Confocal Microscopy Evidence of Prion Protein Fragment hPrP[173-195] Internalization in Rat B104 Neuroblastoma Cell Line

Title: Confocal Microscopy Evidence of Prion Protein Fragment hPrP[173-195] Internalization in Rat B104 Neuroblastoma Cell Line

Volume: 16 Issue: 11

Author(s): Emanuela Urso, Raffaele Acierno, Maria Giulia Lionetto, Antonia Rizzello, Andrea Papa, Trifone Schettino and Michele Maffia

Affiliation:

Keywords: Prion disease, cellular prion protein (PrPC), helix-2, structural ambivalence, synthetic prion peptides, confocal microscopy

Abstract: The cytotoxicity of hPrP[173-195] prion peptide against a neuroblastoma cell model was found independent of its tendency to aggregate over time. Cytosolic and nuclear inclusions of peptide were highlighted by confocal microscopy, suggesting a role as a transcription factor in activating signal transduction pathways involved in cell toxicity.

Cite this article as:

Urso Emanuela, Acierno Raffaele, Lionetto Giulia Maria, Rizzello Antonia, Papa Andrea, Schettino Trifone and Maffia Michele, Confocal Microscopy Evidence of Prion Protein Fragment hPrP[173-195] Internalization in Rat B104 Neuroblastoma Cell Line, Protein & Peptide Letters 2009; 16(11) . https://dx.doi.org/10.2174/092986609789353655