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Inflammation & Allergy - Drug Targets (Discontinued)

Editor-in-Chief

ISSN (Print): 1871-5281
ISSN (Online): 2212-4055

Leptin in Non-Autoimmune Inflammation

Author(s): Chunlin Cai, Bevra H. Hahn, Giuseppe Matarese and Antonio La Cava

Volume 8, Issue 4, 2009

Page: [285 - 291] Pages: 7

DOI: 10.2174/187152809789352168

Price: $65

Abstract

Leptin is an adipokine that modulates multiple functions including energy homeostasis, thermoregulation, bone metabolism, endocrine and pro-inflammatory immune responses. Several studies have implicated leptin in the pathogenesis of chronic autoimmune inflammatory conditions such as autoimmune encephalomyelitis, intestinal bowel inflammation and type-1 diabetes. This review focuses on the role of leptin in non-autoimmune inflammatory diseases that include renal, liver and lung inflammation, atherosclerosis and metabolic syndrome, Behcets disease and endometriosis.

Keywords: Leptin, inflammation, metabolism


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