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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

A New, Efficient Entry to Non-Lipophilic H-Phosphonate Monoesters – Preparation of Anti-HIV Nucleotide Analogues

Author(s): Joanna Romanowska, Agnieszka Szymanska-Michalak, Malgorzata Pietkiewicz, Michal Sobkowski, Jerzy Boryski, Jacek Stawinski and Adam Kraszewski

Volume 6, Issue 6, 2009

Page: [496 - 499] Pages: 4

DOI: 10.2174/157017809789124821

Price: $65

Abstract

Crystalline ammonium (9H-fluoren-9-yl)methyl H-phosphonate was prepared by a new, simple method and it was used as the reagent of choice for the introduction of an H-phosphonate monoester functionality into non-lipophilic anti-HIV nucleoside analogues.

Keywords: H-phosphonates, phosphonylating agents, nucleoside analogues, nucleoside H-phosphonates, protecting groups, β-elimination


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