Abstract
Palladium(0)-catalyzed allylation of soft nucleophiles is a powerful synthetic methodology for the construction of carboncarbon or carbon-heteroatom bonds. The possibility of controlling the regioselectivity is one of the most interesting aspects of this chemistry. In this review, the different factors that can affect the regiochemistry of the nucleophilic attack will be discussed.
Keywords: Palladium, allylic substitution, regioselectivity, soft nucleophiles, ligands, steric effects
Current Organic Synthesis
Title: Control of the Regioselectivity in Palladium(0)-Catalyzed Allylic Alkylation
Volume: 6 Issue: 3
Author(s): Stephanie Norsikian and Chih-Wei Chang
Affiliation:
Keywords: Palladium, allylic substitution, regioselectivity, soft nucleophiles, ligands, steric effects
Abstract: Palladium(0)-catalyzed allylation of soft nucleophiles is a powerful synthetic methodology for the construction of carboncarbon or carbon-heteroatom bonds. The possibility of controlling the regioselectivity is one of the most interesting aspects of this chemistry. In this review, the different factors that can affect the regiochemistry of the nucleophilic attack will be discussed.
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Cite this article as:
Norsikian Stephanie and Chang Chih-Wei, Control of the Regioselectivity in Palladium(0)-Catalyzed Allylic Alkylation, Current Organic Synthesis 2009; 6 (3) . https://dx.doi.org/10.2174/157017909788921880
DOI https://dx.doi.org/10.2174/157017909788921880 |
Print ISSN 1570-1794 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6271 |
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