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Infectious Disorders - Drug Targets

Editor-in-Chief

ISSN (Print): 1871-5265
ISSN (Online): 2212-3989

The Role of Melatonin in Rheumatic Diseases

Author(s): B. Kalpakcioglu and K. Senel

Volume 9, Issue 4, 2009

Page: [453 - 456] Pages: 4

DOI: 10.2174/187152609788922546

Price: $65

Abstract

Melatonin is a neurohormone that has attracted a great deal of attention, being frequently investigated in recent years. Due to its wide-spectrum of properties, melatonin has been suggested to be effective with respect to the etiology and treatment of several diseases. Its action on the immune system and antioxidant features has brought interest to this hormones role in chronic inflammatory diseases. Furthermore, the detection of a correlation between the circadian release of melatonin and the rhythmic symptoms and signs of rheumatoid patients has led scientists to address its involvement in rheumatic diseases. Studies with suitable methodologies and broad perspectives are required in order to determine the functions of this neurohormone, whose effects are dependent on its physiological and pharmacological doses.

Keywords: Melatonin, rhematoid arthritis, fibromyalgia, antioxidant, circadian rhythm


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