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Letters in Organic Chemistry


ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Solvent-Free Synthesis of 1,3-Diphenyl-5-arylpyrazole Derivatives

Author(s): Ji-Tai Li, Ying Yin and Xian-Tao Meng

Volume 6, Issue 5, 2009

Page: [384 - 386] Pages: 3

DOI: 10.2174/157017809788681383

Price: $65


The synthesis of 1,3-diphenyl-5-arylpyrazoles via the reactions of 2,3-epoxy-1-phenyl-3-aryl-1-propanones with phenylhydrazine was carried out in 48-84% yields at 230 °C under solvent-free condition within 1.5 h. This method provides several advantages such as operational simplicity, higher yield and solvent-free.

Keywords: cyclization, 1,3-diphenyl-5-arylpyrazole, synthesis, solvent-free reaction, heterocycles

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