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Inflammation & Allergy - Drug Targets (Discontinued)

Editor-in-Chief

ISSN (Print): 1871-5281
ISSN (Online): 2212-4055

Mechanism of Action of Flavonoids as Anti-inflammatory Agents: A Review

Author(s): Permender Rathee, Hema Chaudhary, Sushila Rathee, Dharmender Rathee, Vikash Kumar and Kanchan Kohli

Volume 8, Issue 3, 2009

Page: [229 - 235] Pages: 7

DOI: 10.2174/187152809788681029

Price: $65

Abstract

Flavonoids are polyphenolic compounds that occur ubiquitously in plants having a variety of biological effects both in vitro and in vivo. They have been found to have antimicrobial, antiviral, anti-ulcerogenic, cytotoxic, antineoplastic, mutagenic, antioxidant, antihepatotoxic, antihypertensive, hypolipidemic, antiplatelet and anti-inflammatory activities. Flavonoids also have biochemical effects, which inhibit a number of enzymes such as aldose reductase, xanthine oxidase, phosphodiesterase, Ca+2-ATPase, lipoxygenase, cycloxygenase, etc. They also have a regulatory role on different hormones like estrogens, androgens and thyroid hormone. They have been found to have anti-inflammatory activity in both proliferative and exudative phases of inflammation. Several mechanisms of action have been proposed to explain anti-inflammatory action of flavonoids. The aim of the present review is to give an overview of the mechanism of action of potential anti-inflammatory flavonoids.

Keywords: Flavonoids, inflammation, anti-inflammatory, lipoxygenases, cyclooxygenase activity


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