Medicinal Chemistry and Anti-Inflammatory Activity of Nitric Oxide-Releasing NSAI Drugs

Esra      Koc; S.   Guniz   Kucukguzel

Abstract

Nitric Oxide, which acts as a non-specific cytotoxic mediator and a biological messenger on immunological competence, has been gaining significantly increasing importance. As an alternative to conventional NSAIDs having significant side effects, pharmacologically improved and therapeutically enhanced NO releasing non-steroidal antiinflammatory drugs with less side effects are being planned to produce.

Keywords: Nitric oxide, NO-NSAID, anti-inflammatory

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