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Protein & Peptide Letters


ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Gastrulation Defective Protease Interacts with Anionic Components of the Drosophila Ovary Extracellular Matrix

Author(s): Sangeetha Sukumari-Ramesh and Ellen K. LeMosy

Volume 16 , Issue 4 , 2009

Page: [437 - 443] Pages: 7

DOI: 10.2174/092986609787848135

Price: $65


The Drosophila proteases Gastrulation Defective and Snake function in embryonic polarity establishment and bind heparin, a surrogate for anionic species present in the extracellular matrix. Here we demonstrate binding of GD, but not Snake, to anionic species that appear to be tightly associated with a highly purified eggshell matrix.

Keywords: Gastrulation Defective, Snake, Pipe, embryonic polarity, serine protease cascade, Drosophila

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