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Protein & Peptide Letters


ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Stability Check of Succinylated Concanavalin A: Presence of Functionally Active Conformational State

Author(s): Sadaf Fatima and Rizwan Hasan Khan

Volume 16 , Issue 4 , 2009

Page: [423 - 429] Pages: 7

DOI: 10.2174/092986609787848117

Price: $65


The equilibrium denaturation pathway of Succinyl Con A exhibited three-state mechanism with the transition midpoints at 1 and 3 M GdnHCl and at 2.6 and 5 M urea. Unfolding resulted in stabilization of molten-globule (MG) like intermediate states at 2 M GdnHCl and 3 M urea. It was particularly interesting that state obtained at 3 M urea was functionally active.

Keywords: Succinylated Con A, Molten Globule like state, equilibrium denaturation, guanidine hydrochloride, urea

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