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Protein & Peptide Letters

Editor-in-Chief

ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

The TPR2B Domain of the Hsp70/Hsp90 Organizing Protein (Hop) May Contribute Towards Its Dimerization

Author(s): Victoria M. Longshaw, Linda L. Stephens, Sheril Daniel and Gregory L. Blatch

Volume 16 , Issue 4 , 2009

Page: [402 - 407] Pages: 6

DOI: 10.2174/092986609787848162

Price: $65

Abstract

The role of the TPR2B domain of Hop is as yet unknown. We have shown here by site directed mutagenesis and size exclusion chromatography for the first time that the TPR1 and TPR2B domains of Hop independently dimerized, and that the dimerization of TPR2B was not dependent on its predicted two-carboxylate clamp residues. Furthermore, our data indicated that the dimerization of Hop and its domains was not disrupted in the presence of Hsp70 and Hsp90 peptides.

Keywords: Hop, dimerization, tetratricopeptide repeat domain, TPR


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