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Protein & Peptide Letters

Editor-in-Chief

ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Prediction of Cell Wall Lytic Enzymes Using Chous Amphiphilic Pseudo Amino Acid Composition

Author(s): Hui Ding, Liaofu Luo and Hao Lin

Volume 16 , Issue 4 , 2009

Page: [351 - 355] Pages: 5

DOI: 10.2174/092986609787848045

Price: $65

Abstract

Discriminating cell wall lytic enzymes from non lytic enzymes is a very important task for curing bacterial infections. In this paper, based on Chous amphiphilic pseudo amino acid composition, we develop fisher-discriminant based classifier to predict cell wall lytic enzymes. Experiments show that 66.7% sensitivity with 88.6% specificity is obtained. The method is further able to predict endolysin and autolysin with an overall accuracy of 92.9%. Results demonstrated that our method can provide highly useful information for further bacterial control research.

Keywords: Lytic enzyme, endolysin, autolysin, Chou's amphiphilic pseudo amino acid composition


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