Bismuth Nitrate Promoted Fischer Indole Synthesis: A Simple and Convenient Approach for the Synthesis of Alkyl Indoles

Title: Bismuth Nitrate Promoted Fischer Indole Synthesis: A Simple and Convenient Approach for the Synthesis of Alkyl Indoles

Volume: 6 Issue: 2

Author(s): Aralihalli Sudhakara, Honnali Jayadevappa, Hosanagara N.H. Kumar and Kittappa M. Mahadevan

Affiliation:

Keywords: One pot, Fischer indole synthesis, bismuth nitrate, phenyl hydrazine hydrochloride, cyclohexanone, ethyl methyl ketone

Abstract: A novel one-pot fisher indole synthesis approach has been developed by using bismuth nitrate as a catalyst. Yields around 90-95% were obtained after reaction in methanol at reflux temperature in 20-40 min. Apart from the mild reaction conditions of the process and its excellent results, the simplicity of product isolation and the possibility to recycle the bismuth nitrate offers a significant advantage.

Cite this article as:

Sudhakara Aralihalli, Jayadevappa Honnali, Kumar N.H. Hosanagara and Mahadevan M. Kittappa, Bismuth Nitrate Promoted Fischer Indole Synthesis: A Simple and Convenient Approach for the Synthesis of Alkyl Indoles, Letters in Organic Chemistry 2009; 6(2) . https://dx.doi.org/10.2174/157017809787582735