Generic placeholder image

Letters in Organic Chemistry


ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Bismuth Nitrate Promoted Fischer Indole Synthesis: A Simple and Convenient Approach for the Synthesis of Alkyl Indoles

Author(s): Aralihalli Sudhakara, Honnali Jayadevappa, Hosanagara N.H. Kumar and Kittappa M. Mahadevan

Volume 6, Issue 2, 2009

Page: [159 - 164] Pages: 6

DOI: 10.2174/157017809787582735

Price: $65


A novel one-pot fisher indole synthesis approach has been developed by using bismuth nitrate as a catalyst. Yields around 90-95% were obtained after reaction in methanol at reflux temperature in 20-40 min. Apart from the mild reaction conditions of the process and its excellent results, the simplicity of product isolation and the possibility to recycle the bismuth nitrate offers a significant advantage.

Keywords: One pot, Fischer indole synthesis, bismuth nitrate, phenyl hydrazine hydrochloride, cyclohexanone, ethyl methyl ketone

Rights & Permissions Print Export Cite as
© 2023 Bentham Science Publishers | Privacy Policy