Generic placeholder image

Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Lysophospholipids: Their Generation, Physiological Role and Detection. Are They Important Disease Markers?

Author(s): Beate Fuchs and Jurgen Schiller

Volume 9, Issue 3, 2009

Page: [368 - 378] Pages: 11

DOI: 10.2174/1389557510909030368

Price: $65


The concentration of lysophospholipids (LPL) increases under pathological conditions and, thus, LPL attract diagnostic and pharmacological interest. LPL are particularly interesting because they possess pro- and anti-inflammatory properties and can be generated by phospholipases and reactive oxygen species (ROS). This review provides an overview of the mechanisms by which LPL are generated and how they can be determined. The effects of LPL as signaling molecules and their roles in different pathologies are discussed. The focus will be on lysophosphatidylcholine (LPC).

Keywords: Lysophospholipids, Phospholipids, Lysophosphatidylcholine, Phospholipase, Reactive Oxygen Species, Inflammation, Disease Markers, Signaling Molecules

Rights & Permissions Print Export Cite as
© 2023 Bentham Science Publishers | Privacy Policy