Synthesis of 3-Arylpropenal and 3-Arylpropionic Acids by Palladium Catalysed Heck Coupling Reactions: Scopes and Limitations

Title: Synthesis of 3-Arylpropenal and 3-Arylpropionic Acids by Palladium Catalysed Heck Coupling Reactions: Scopes and Limitations

Volume: 6 Issue: 1

Author(s): Laurent Djakovitch and Catherine Pinel

Affiliation:

Keywords: 3-arylpropenal, 3-arylpropionic acids, Heck coupling reaction, palladium, homogeneous catalysis, heterogeneous catalysis

Abstract: Several classical methods were described for the selective synthesis of cinnamaldehyde derivatives and 3-arylpropionic acids but their applicability remains limited due to the difficult and costly synthesis of the starting materials. Since few years, palladium catalyzed procedure has been reported. Whatever they use homogeneous or heterogeneous palladium catalysts, these catalytic methods offer viable environmental friendly alternatives to stoechiometric methods particularly since they generally required a single reaction step starting from simple substrates. Some of these new methods are really considered as green alternatives since they use heterogeneous easily separable (and recyclable) palladium catalysts. This review article summarizes the literature on this area. It is ended by mechanistic considerations.

Cite this article as:

Djakovitch Laurent and Pinel Catherine, Synthesis of 3-Arylpropenal and 3-Arylpropionic Acids by Palladium Catalysed Heck Coupling Reactions: Scopes and Limitations, Current Organic Synthesis 2009; 6 (1) . https://dx.doi.org/10.2174/157017909787314876