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Protein & Peptide Letters


ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Proteinase K-Resistant Aggregates of Recombinant Prion Protein PrP-(23-98) Are Toxic to Cultured Cells

Author(s): Noriyuki Shiraishi, Yoko Inai and Yoshito Ihara

Volume 16, Issue 1, 2009

Page: [91 - 96] Pages: 6

DOI: 10.2174/092986609787049475

Price: $65


Here, we show for the first time that non-fibrillar and spherical aggregates produced from PrP-(23-98) in the presence of NADPH plus copper ions are toxic to cultured cells and induce apoptotic signals. It is also confirmed that endogenous cellular PrP isoform is not required for toxicity to occur.

Keywords: Prion protein, PrP-(23-98), aggregates, cytotoxicity, apoptosis, PrP-deficient cell line

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