Abstract
A variety of imidazolones 1-34 derivatives were synthesized and tested for their antibacterial effects against Escherichia coli, Bacillus subtilis, Shigella flexnari, Staphylococcus aureus, Pseudomonas aeruginosa, Salmonella typhi. Compound 18 found to be moderately active against S. flexnari, however, compounds 8, 11, 15, 21, 22, 25 showed to be moderate and compounds 31 and 34 exhibited good activities against P. aeruginosa. Compounds 7, 9, 12-14, 24-26, and 29 demonstrated good to excellent activity against S. typhi, while remaining compound did not show significant antibacterial activities. Compounds 7, 9, 12, 13, 14, 25, 26, 29 showed good activities against S. typhi. The antifungal activities of imidazolones were also determined against Trichophyton longifusus, Candida albicans, Aspergillus flavus, Microsporum canis, Fusarium solani, Candida glabrata and found that compounds showed varying degree of percentage inhibition.
Keywords: Synthesis, Imidazolone, Antifungal, Antibacterial activities
Letters in Drug Design & Discovery
Title: Synthesis and Antibacterial and Antifungal Activity of 5-Substituted Imidazolones
Volume: 6 Issue: 1
Author(s): Khalid Mohammed Khan, Uzma Rasool Mughal, Sadia Khan, Saira Khan, Shahnaz Perveen and M. Iqbal Choudhary
Affiliation:
Keywords: Synthesis, Imidazolone, Antifungal, Antibacterial activities
Abstract: A variety of imidazolones 1-34 derivatives were synthesized and tested for their antibacterial effects against Escherichia coli, Bacillus subtilis, Shigella flexnari, Staphylococcus aureus, Pseudomonas aeruginosa, Salmonella typhi. Compound 18 found to be moderately active against S. flexnari, however, compounds 8, 11, 15, 21, 22, 25 showed to be moderate and compounds 31 and 34 exhibited good activities against P. aeruginosa. Compounds 7, 9, 12-14, 24-26, and 29 demonstrated good to excellent activity against S. typhi, while remaining compound did not show significant antibacterial activities. Compounds 7, 9, 12, 13, 14, 25, 26, 29 showed good activities against S. typhi. The antifungal activities of imidazolones were also determined against Trichophyton longifusus, Candida albicans, Aspergillus flavus, Microsporum canis, Fusarium solani, Candida glabrata and found that compounds showed varying degree of percentage inhibition.
Export Options
About this article
Cite this article as:
Khan Mohammed Khalid, Mughal Rasool Uzma, Khan Sadia, Khan Saira, Perveen Shahnaz and Choudhary Iqbal M., Synthesis and Antibacterial and Antifungal Activity of 5-Substituted Imidazolones, Letters in Drug Design & Discovery 2009; 6 (1) . https://dx.doi.org/10.2174/157018009787158553
DOI https://dx.doi.org/10.2174/157018009787158553 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Application of Multimodal MR Imaging on Studying Alzheimer's Disease: A Survey
Current Alzheimer Research Neural Stem Cell Transplantation and CNS Diseases
CNS & Neurological Disorders - Drug Targets Chemopreventive Properties of Tolfenamic Acid: A Mechanistic Review
Current Medicinal Chemistry Cardiac Toxicities of Antiangiogenic Therapies
Current Angiogenesis (Discontinued) Secretory Clusterin as a Novel Molecular-targeted Therapy for Inhibiting Hepatocellular Carcinoma Growth
Current Medicinal Chemistry Structure and Function of Poly(ADP-ribose) Polymerase-1: Role in Oxidative Stress-Related Pathologies
Current Vascular Pharmacology Using Digital and Social Media Metrics to Develop Mental Health Approaches for Youth
Adolescent Psychiatry Synthesis of Imidazo[1,2-b]pyridazine Comprised Piperazine, Morpholine Derivatives as Potent Antimycobacterial Agents with In Vivo Locomotor Activity
Anti-Infective Agents Synthesis of Novel 4-Aryl-1,2,3,4-tetrahydroisoquinolines as Probes for Dopamine Receptor Ligands
Medicinal Chemistry Prime Time for G-Protein-Coupled Receptor Heteromers as Therapeutic Targets for CNS disorders: The Dopamine D1-D3 Receptor Heteromer
CNS & Neurological Disorders - Drug Targets Efficacy of Sofosbuvir Plus Ribavirin with or Without Peginterferon- Alfa in Treatment of a Cohort of Egyptian Patients with Hepatitis C Virus Infection
Infectious Disorders - Drug Targets Endoplasmic Reticulum Stress Signaling Pathways: Activation and Diseases
Current Protein & Peptide Science Pharmacological Studies of Smooth Pursuit and Antisaccade Eye Movements in Schizophrenia: Current Status and Directions for Future Research
Current Neuropharmacology Targeting the Ubiquitin-Proteasome Pathway: An Emerging Concept in Cancer Therapy
Current Topics in Medicinal Chemistry Genes, Blame and Loss of Control: is there a Place in Criminal Law for a ‘Genetic Defense’?
Recent Advances in DNA & Gene Sequences (Discontinued) Secondary Stroke Prevention in Patients with Cryptogenic Stroke and Patent Foramen Ovale
Vascular Disease Prevention (Discontinued) Intranasal Drug Delivery for Brain Targeting
Current Drug Delivery Synthesis and Biological Activity of Novel N-glucosides Containing Substituted Piperazine Moiety
Letters in Drug Design & Discovery Chemotherapeutic Properties of n-3 Polyunsaturated Fatty Acids - Old Concepts and New Insights
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Discovery of Anti-Alzheimer Agents: Current Ligand-Based Approaches toward the Design of Acetylcholinesterase Inhibitors
Mini-Reviews in Medicinal Chemistry