Abstract
Transcranial magnetic stimulation (TMS) is a safe and easy technique for stimulating neurons in the human central nervous system. Studies combining TMS with drugs in healthy subjects and patients have advanced our knowledge of how TMS activates brain circuits and led to new techniques for evaluating the function of specific systems. For example, TMS techniques can detect effects on axon membranes, glutamatergic and GABAergic synapses and the influence of catecholaminergic systems, as well as group differences due to genetic variations in the response to drugs. With this knowledge base, TMS can now be used to explore and compare the effects of drugs on brain systems and may also serve as a surrogate for behavioral responses in clinical trials.
Keywords: Transcranial magnetic stimulation (single pulse), transcranial magnetic stimulation (paired pulse), drug physiological effects, neurotransmitter agents, gaba, glutamate, monoamines, biogenic
Central Nervous System Agents in Medicinal Chemistry
Title: Transcranial Magnetic Stimulation in Clinical Pharmacology
Volume: 8 Issue: 4
Author(s): Dimitrios Kapogiannis and Eric M. Wassermann
Affiliation:
Keywords: Transcranial magnetic stimulation (single pulse), transcranial magnetic stimulation (paired pulse), drug physiological effects, neurotransmitter agents, gaba, glutamate, monoamines, biogenic
Abstract: Transcranial magnetic stimulation (TMS) is a safe and easy technique for stimulating neurons in the human central nervous system. Studies combining TMS with drugs in healthy subjects and patients have advanced our knowledge of how TMS activates brain circuits and led to new techniques for evaluating the function of specific systems. For example, TMS techniques can detect effects on axon membranes, glutamatergic and GABAergic synapses and the influence of catecholaminergic systems, as well as group differences due to genetic variations in the response to drugs. With this knowledge base, TMS can now be used to explore and compare the effects of drugs on brain systems and may also serve as a surrogate for behavioral responses in clinical trials.
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Cite this article as:
Kapogiannis Dimitrios and Wassermann M. Eric, Transcranial Magnetic Stimulation in Clinical Pharmacology, Central Nervous System Agents in Medicinal Chemistry 2008; 8 (4) . https://dx.doi.org/10.2174/187152408786848076
DOI https://dx.doi.org/10.2174/187152408786848076 |
Print ISSN 1871-5249 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6166 |
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