Correlation Between Circulating Adhesion Molecules and Resistin Levels in Hypertensive Type-2 Diabetic Patients

Jose      Juan Lozano-Nuevo; Teresa      Estrada-Garcia; Hilda      Vargas-Robles; Bruno      A. Escalante-Acosta; Alberto      F. Rubio-Guerra

Abstract

Background: Endothelial dysfunction, a common feature among hypertensive and type-2 diabetic patients, has been associated with inflammation and increased concentrations of serum soluble adhesion molecules and resistin, a monocyte-macrophage- and adipocyte-derived cytokine.

The Aim of this Study: To determine if there is a correlation between the serum concentrations of ICAM-1, VCAM-1, Eselectin and resistin in hypertensive type-2 diabetic patients.

Methods: Thirty hypertensive type-2 diabetic patients were enrolled in the study. Serum ICAM-1, VCAM-1, E-selectin and resistin concentrations were determined by ELISA and correlated with the Spearman correlation coefficient.

Results: The patients' serum resistin concentrations significantly correlated with VCAM-1 (r = 0.31, p = 0.05) concentrations but not with ICAM-1 (r = 0.29, p = > 0.05) and E-selectin (r = 0.10, p = 0.24) concentrations. Conclusion: VCAM-1 and resistin may participate in the pathophysiology of vascular damage in hypertensive type-2 diabetic patients. Serum resistin concentrations may be a marker of endothelial dysfunction.

Keywords: Circulating adhesion molecules, resistin, hypertension, type 2 diabetes mellitus, inflammation, microvascular complications, endothelial function, atherosclerotic complications, Endothelial dysfunction, glycoprotein, immunoglobulin superfamily, leukocyte, arterial walls, diabetes mellitus, coronary heart disease, Serum, renin-angiotensin-aldosterone, blood glucose, heart, hepatic, renal failure, alvular heart disease, acute coronary syndrome, autoimmune disease, pregnancy, urinary tract, alcohol, lipolysis, diacylglycerols, phosphorylation, insulin resistance