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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Antioxidant Therapy in Alzheimers Disease: Theory and Practice

Author(s): Gjumrakch Aliev, Mark E. Obrenovich, V. Prakash Reddy, Justin C. Shenk, Paula I. Moreira, Akihiko Nunomura, Xiongwei Zhu, Mark A. Smith and George Perry

Volume 8, Issue 13, 2008

Page: [1395 - 1406] Pages: 12

DOI: 10.2174/138955708786369582

Price: $65

Abstract

Alzheimer disease treatment has yet to yield a successful therapy that addresses the source of the damage found in brains. Of the varied proposed theories of AD etiology, reactive oxygen species (ROS) generation is cited as a common factor. Efforts to reduce the pathology associated with ROS via antioxidants therefore offer new hope to patients suffering from this devastative disease.

Keywords: Antioxidant, calorie restriction, estrogen, free radical, glutathione, oxidation, oxidative stress, therapy


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