Abstract
The first three-component coupling reactions between various anilines (1), benzaldehydes (2), and cyclohexen- 2-one (3) were performed under mild conditions (acetonitrile, room temperature, 14 h) in the presence of 20 mol % BiCl3 to obtain new 2,3-diaryl-2-aza[2.2.2]octan-5-ones (4,5) with interesting acetylcholinesterase inhibitory properties.
Keywords: 2,3-Diaryl-2-azabicyclo[2.2.2]octan-5-one, catalysed three-component aza Diels-Alder reaction, acetylcholinesterase inhibitors
Letters in Organic Chemistry
Title: An Efficient Synthesis of 2,3-Diaryl-2-azabicyclooctanones Via BiCl3- Catalysed Three-Component aza Diels-Alder Reaction
Volume: 5 Issue: 7
Author(s): Luis Astudillo S., Gabriel A. Vallejos, Nestor Correa, Margarita Gutierrez C., Walesca de la Guarda and Vladimir V. Kouznetsov
Affiliation:
Keywords: 2,3-Diaryl-2-azabicyclo[2.2.2]octan-5-one, catalysed three-component aza Diels-Alder reaction, acetylcholinesterase inhibitors
Abstract: The first three-component coupling reactions between various anilines (1), benzaldehydes (2), and cyclohexen- 2-one (3) were performed under mild conditions (acetonitrile, room temperature, 14 h) in the presence of 20 mol % BiCl3 to obtain new 2,3-diaryl-2-aza[2.2.2]octan-5-ones (4,5) with interesting acetylcholinesterase inhibitory properties.
Export Options
About this article
Cite this article as:
S. Astudillo Luis, Vallejos A. Gabriel, Correa Nestor, C. Gutierrez Margarita, de la Guarda Walesca and Kouznetsov V. Vladimir, An Efficient Synthesis of 2,3-Diaryl-2-azabicyclooctanones Via BiCl3- Catalysed Three-Component aza Diels-Alder Reaction, Letters in Organic Chemistry 2008; 5 (7) . https://dx.doi.org/10.2174/157017808785982301
DOI https://dx.doi.org/10.2174/157017808785982301 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Advanced Drug Delivery of N-Acetylcarnosine (N-Acetyl-beta-alanyl-Lhistidine), Carcinine (Beta-alanylhistamine) and L-carnosine (Beta-alanyl- L-histidine) in Targeting Peptide Compounds as Pharmacological Chaperones for Use in Tissue Engineering, Human Disease Management and Therapy: From in vitro to the Clinic
Recent Patents on Drug Delivery & Formulation Synthesis, Antimicrobial Evaluation and Docking Study of Novel 3,5-Disubstituted-2-Isoxazoline and 1,3,5-Trisubstituted-2-Pyrazoline Derivatives
Medicinal Chemistry Insights on Antimicrobial Resistance, Biofilms and the Use of Phytochemicals as New Antimicrobial Agents
Current Medicinal Chemistry The HLA Region and Autoimmune Disease: Associations and Mechanisms of Action
Current Genomics Severe Influenza: Clinical Features and Treatment Options
Current Respiratory Medicine Reviews Synthesis and SAR Study of Simple Aryl Oximes and Nitrofuranyl Derivatives with Potent Activity Against Mycobacterium tuberculosis
Letters in Drug Design & Discovery Small-Molecule Modulators of the NF-κB Pathway Newly Identified by a Translocation-Based Cellular Assay
Current Topics in Medicinal Chemistry Green Tea Polyphenols as Proteasome Inhibitors: Implication in Chemoprevention
Current Cancer Drug Targets Development of Ribonucleotide Reductase Inhibitors: A Review on Structure Activity Relationships
Mini-Reviews in Medicinal Chemistry QSAR Study On 5-Lipoxygenase Inhibitors Based on Support Vector Machine
Medicinal Chemistry Anti-inflammatory Effects of Dietary Antioxidants
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents Design of Cathepsin K Inhibitors for Osteoporosis
Current Topics in Medicinal Chemistry Aldose Reductase Enzyme and its Implication to Major Health Problems of the 21st Century
Current Medicinal Chemistry New Developments in Inhaled Antibiotics for the Treatment of Pseudomonas aeruginosa
Current Pharmaceutical Design Synthesis, Crystal Structure and Anti-HIV Activity of 2- Adamantyl/adamantylmethyl-5-aryl-1,3,4-oxadiazoles
Medicinal Chemistry Predicting Severe COVID-19 Infection on Initial Diagnosis: Comparison and Validation of CT Imaging Triage Tools
Current Medical Imaging Accelerating Drug Discovery by Integrative Implementation of Laboratory Automation in the Work Flow
Current Medicinal Chemistry Could Growth Factor-Mediated Extracellular Matrix Deposition and Degradation Offer the Ground for Directed Pharmacological Targeting in Fibrosarcoma?
Current Medicinal Chemistry Quantitative Structure – Activity Relationships (QSAR) with the MolNet Molecular Graph Machine
Current Bioinformatics Kv1.5 Blockers for the Treatment of Atrial Fibrillation: Approaches to Optimization of Potency and Selectivity and Translation to In Vivo Pharmacology
Current Topics in Medicinal Chemistry