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Current Protein & Peptide Science

Editor-in-Chief

ISSN (Print): 1389-2037
ISSN (Online): 1875-5550

Discovery of New Therapeutic Targets by the Informational Spectrum Method

Author(s): Nevena Veljkovic, Sanja Glisic, Jelena Prljic, Vladimir Perovic, Maurizio Botta and Veljko Veljkovic

Volume 9, Issue 5, 2008

Page: [493 - 506] Pages: 14

DOI: 10.2174/138920308785915245

Price: $65

Abstract

The field of bioinformatics has become a major part of the drug discovery pipeline playing a key role in improvement and acceleration of this time and money consuming process. Here we review the application of the informational spectrum method (ISM), a virtual spectroscopy method for structure/function analysis of proteins, in identification of functional protein domains representing candidate therapeutic targets for drugs against human immunodeficiency virus (HIV)-1, anthrax, highly pathogenic influenza virus H5N1 and cardiovascular diseases.

Keywords: Bioinformatics, target, electron-ion interaction potential, informational spectrum method, H5N1, HIV-1, anthrax


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