Abstract
Depsipeptides are a large group of natural products produced by fungi, actinomycetes, cyanobacteria, higher plants and marine organisms. This family of compounds is known to exhibit a wide range of biological activities, and thanks to the progress of isolation techniques and the advances of methods for structure determination, the numbers of depsipeptides having both unique structures and attractive biological activities are increasing. Many of these compounds have shown a wide range of biological activities, and some are in clinical use or have entered human clinical trials as antibiotic or anticancer agents. However, only a handful of them have been evaluated for their antimalarial activity. This paper aims to review the recent advances in depsipeptides as potential antimalarial compounds.
Keywords: Depsipeptides, Microorganisms, Antimalarials, actinomycetes, cyanobacteria, marine organisms, biological activities, isolation techniques, anticancer agents
Mini-Reviews in Medicinal Chemistry
Title: Depsipeptides from Microorganisms: A New Class of Antimalarials
Volume: 8 Issue: 11
Author(s): Jean Fotie and Rachel E. Morgan
Affiliation:
Keywords: Depsipeptides, Microorganisms, Antimalarials, actinomycetes, cyanobacteria, marine organisms, biological activities, isolation techniques, anticancer agents
Abstract: Depsipeptides are a large group of natural products produced by fungi, actinomycetes, cyanobacteria, higher plants and marine organisms. This family of compounds is known to exhibit a wide range of biological activities, and thanks to the progress of isolation techniques and the advances of methods for structure determination, the numbers of depsipeptides having both unique structures and attractive biological activities are increasing. Many of these compounds have shown a wide range of biological activities, and some are in clinical use or have entered human clinical trials as antibiotic or anticancer agents. However, only a handful of them have been evaluated for their antimalarial activity. This paper aims to review the recent advances in depsipeptides as potential antimalarial compounds.
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Cite this article as:
Fotie Jean and Morgan E. Rachel, Depsipeptides from Microorganisms: A New Class of Antimalarials, Mini-Reviews in Medicinal Chemistry 2008; 8 (11) . https://dx.doi.org/10.2174/138955708785909916
DOI https://dx.doi.org/10.2174/138955708785909916 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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