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Protein & Peptide Letters


ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Aptabodies – New Type of Artificial Receptors for Detection Proteins

Author(s): T. Hianik, A. Porfireva, I. Grman and G. Evtugyn

Volume 15, Issue 8, 2008

Page: [799 - 805] Pages: 7

DOI: 10.2174/092986608785203656

Price: $65


We report on a new type of artificial receptor formed by hybridization of two DNA aptamers for human thrombin (aptabody). This aptasensor based on multiwalled carbon nanotubes allowed us to detect thrombin with detection limit of 0.3 nM, which was 3 times better in comparison with conventional aptamer.

Keywords: DNA aptamers, Hybridization, Human thrombin, Multiwalled carbon nanotubes, Biosensor, Electrochemical quartz crystal microbalance

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