Abstract
Alzheimers disease is a complex neurodegenerative disorder with a multifaceted pathogenesis. This fact has long halted the development of effective anti-Alzheimer drugs. Recently, however, basis for a therapeutic strategy based on multi-target-directed ligands has been formed. In this context, dual binding site acetylcholinesterase inhibitors represent a suitable starting point. The rational modification of their structures to provide them with additional biological properties has emerged as a successful approach.
Keywords: Dimeric compounds, bivalent ligands, multimodal therapeutics, multifunctional compounds, multifactorial diseases
Mini-Reviews in Medicinal Chemistry
Title: From Dual Binding Site Acetylcholinesterase Inhibitors to Multi-Target-Directed Ligands (MTDLs): A Step Forward in the Treatment of Alzheimers Disease
Volume: 8 Issue: 10
Author(s): Maria Laura Bolognesi, Anna Minarini, Michela Rosini, Vincenzo Tumiatti and Carlo Melchiorre
Affiliation:
Keywords: Dimeric compounds, bivalent ligands, multimodal therapeutics, multifunctional compounds, multifactorial diseases
Abstract: Alzheimers disease is a complex neurodegenerative disorder with a multifaceted pathogenesis. This fact has long halted the development of effective anti-Alzheimer drugs. Recently, however, basis for a therapeutic strategy based on multi-target-directed ligands has been formed. In this context, dual binding site acetylcholinesterase inhibitors represent a suitable starting point. The rational modification of their structures to provide them with additional biological properties has emerged as a successful approach.
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Cite this article as:
Bolognesi Laura Maria, Minarini Anna, Rosini Michela, Tumiatti Vincenzo and Melchiorre Carlo, From Dual Binding Site Acetylcholinesterase Inhibitors to Multi-Target-Directed Ligands (MTDLs): A Step Forward in the Treatment of Alzheimers Disease, Mini-Reviews in Medicinal Chemistry 2008; 8 (10) . https://dx.doi.org/10.2174/138955708785740652
DOI https://dx.doi.org/10.2174/138955708785740652 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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