New Lanthanide Complexes with Antioxidant Activity

Irena      Kostova; Maria      Traykova; Vinod   K.   Rastogi

Abstract

The cerium (III), lanthanum (III) and neodymium (III) complexes of 5-aminoorotic acid were synthesized and their structures were determined by means of theoretical study, spectral and physicochemical analysis. Significant differences in the spectra of the complexes were observed as compared to the spectra of the ligand. The ligand and the complexes were tested for the antioxidant activity. The results obtained indicate that the tested compounds exerted a considerable antioxidant effect upon the evaluated radicals formation in the blood plasma of Wistar rat.

Keywords: Lanthanide (III) complexes, 5-Aminoorotic acid, antioxidant activity

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Medicinal Chemistry

Title: New Lanthanide Complexes with Antioxidant Activity

Volume: 4 Issue: 4

Author(s): Irena Kostova, Maria Traykova and Vinod K. Rastogi

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Keywords: Lanthanide (III) complexes, 5-Aminoorotic acid, antioxidant activity

Abstract: The cerium (III), lanthanum (III) and neodymium (III) complexes of 5-aminoorotic acid were synthesized and their structures were determined by means of theoretical study, spectral and physicochemical analysis. Significant differences in the spectra of the complexes were observed as compared to the spectra of the ligand. The ligand and the complexes were tested for the antioxidant activity. The results obtained indicate that the tested compounds exerted a considerable antioxidant effect upon the evaluated radicals formation in the blood plasma of Wistar rat.

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Kostova Irena, Traykova Maria and Rastogi K. Vinod, New Lanthanide Complexes with Antioxidant Activity, Medicinal Chemistry 2008; 4 (4) . https://dx.doi.org/10.2174/157340608784872181

DOI https://dx.doi.org/10.2174/157340608784872181	Print ISSN 1573-4064
Publisher Name Bentham Science Publisher	Online ISSN 1875-6638

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